Modelling in tumour biology part II: modelling cancer therapy - 17 Downloads
Modelling in tumour biology part II: modelling concepts
and structures
D. A. Rew
Southampton University Hospitals, UK
Introduction
Most current adjuvant therapy for solid tumours is unsatisfactory. Relapse and treatment failure rates for chemotherapy and radiotherapy are high, as is the morbidity from the toxicity of current treatment strategies. Although we hope for novel therapies, which will destroy established recurrent and metastatic tumours, in clinical practice we must work with the agents and therapeutic tools which we already possess. We thus need to aim for less empiricism in treatment selection and for more scientific targetting of individual patients. Extensive, systematic experimentation on human subjects is rarely practical or ethical, and modelling offers a route to the development of new treatment strategies.
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