c-myc protein product is a marker of DNA synthesis but not of malignancy in human gastrointestinal tissues and tumours - 19 Downloads
c-myc protein product is a marker of DNA synthesis but not of malignancy in human gastrointestinal tissues and tumours
D. A. Rew, I. Taylor, H. Cox*, J. V. Watson* and G. D. Wilson
c-myc is a cellular gene, sited on chromosome 8 at location q24 (Reference 1). It shows differential expression between resting and proliferating cells and is highly conserved between species2-4. Its gene product is a 439-amino acid, 62000 molecular weight phosphoprotein (p62c-myc) whose structure and function have been described5-8. Little is known about its expression in upper gastrointestinal tissues and tumours. The protein can be detected in fresh, ethanol, methanol or formalin fixed specimens using monoclonal antibodies such as 6E10, by multiparameter flow cytometry (MFCM), by Western blotting and by histochemistry. The type of fixative and analysis may have an important bearing on the results obtained.
To view full paper, download PDF
