Advances in cell kinetics
David A. Rew, GEORGE D. WILSON
Abnormal proliferation of cells is an important feature of many diseases, particularly malignancy. Knowledge of the proliferative characteristics, or cell kinetics, of tumours may help to unravel the disease process and to optimise the timing of treatment. Proliferating cells pass through a series of discrete phases in their life cycle. Howard and Pelc, responsible for the modern concept of the cell cycle, described five phases.¹ From the G1 (gap 1) phase cells enter either the G0 (resting) or S (DNA synthesis) phase. From the S phase they enter the G2 (gap 2) phase, from which they pass into the M (mitosis) phase and then back into G1. Chromosomes are duplicated during the S phase.
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